ParkDB: A Parkinson's disease gene expression database

Cristian Taccioli, Vincenza Maselli, Jesper Tegnér, David Gomez-Cabrero, Gioia Altobelli, Warren Emmett, Francesco Lescai, Stefano Gustincich, Elia Stupka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Parkinson's disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-Analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species.

Original languageEnglish (US)
Article numberbar007
JournalDatabase
Volume2011
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Information Systems
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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