Parente2: a fast and accurate method for detecting identity by descent

Jesse M. Rodriguez, Sivan Bercovici, Lin Huang, Roy Frostig, Serafim Batzoglou

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Identity-by-descent (IBD) inference is the problem of establishing a genetic connection between two individuals through a genomic segment that is inherited by both individuals from a recent common ancestor. IBD inference is an important preceding step in a variety of population genomic studies, ranging from demographic studies to linking genomic variation with phenotype and disease. The problem of accurate IBD detection has become increasingly challenging with the availability of large collections of human genotypes and genomes: Given a cohort's size, a quadratic number of pairwise genome comparisons must be performed. Therefore, computation time and the false discovery rate can also scale quadratically. To enable accurate and efficient large-scale IBD detection, we present Parente2, a novel method for detecting IBD segments. Parente2 is based on an embedded log-likelihood ratio and uses a model that accounts for linkage disequilibrium by explicitly modeling haplotype frequencies. Parente2 operates directly on genotype data without the need to phase data prior to IBD inference. We evaluate Parente2's performance through extensive simulations using real data, and we show that it provides substantially higher accuracy compared to previous state-of-the-art methods while maintaining high computational efficiency.
Original languageEnglish (US)
Pages (from-to)280-289
Number of pages10
JournalGenome Research
Volume25
Issue number2
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint Dive into the research topics of 'Parente2: a fast and accurate method for detecting identity by descent'. Together they form a unique fingerprint.

Cite this