Oxidative Addition to Palladium(0) Made Easy through Photoexcited-State Metal Catalysis: Experiment and Computation

Rajesh Kancherla, Krishnamoorthy Muralirajan, Bholanath Maity, Chen Zhu, Patricia E. Krach, Luigi Cavallo, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Visible-light induced, palladium catalyzed alkylations of α,β-unsaturated acids with unactivated alkyl bromides are described. A variety of primary, secondary, and tertiary alkyl bromides are activated by the photoexcited palladium metal catalyst to provide a series of olefins at room temperature under mild reaction conditions. Mechanistic investigations and density functional theory (DFT) studies suggest that a photoinduced inner-sphere mechanism is operative in which a barrierless, single-electron transfer oxidative addition of the alkyl halide to Pd is key for the efficient transformation.
Original languageEnglish (US)
Pages (from-to)3412-3416
Number of pages5
JournalAngewandte Chemie International Edition
Volume58
Issue number11
DOIs
StatePublished - Jan 9 2019

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