Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates

Claudio U. Köser, Stefan Niemann, David K. Summers, John A.C. Archer

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..
Original languageEnglish (US)
Pages (from-to)807-810
Number of pages4
JournalInfection, Genetics and Evolution
Volume12
Issue number4
DOIs
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Infectious Diseases
  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Microbiology (medical)

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