Organocatalytic enantioselective reduction of pyridines

Magnus Rueping*, Andrey P. Antonchick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

231 Scopus citations

Abstract

Metal-free at last! The first enantioselective organocatalytic reduction of pyridine derivatives leads to hexahydrochinolinones and tetrahydropyridines in good yields and with excellent enantioselctivities (up to 92% ee; see scheme). These compounds are starting materials for the synthesis of various natural products.

Original languageEnglish (US)
Pages (from-to)4562-4565
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number24
DOIs
StatePublished - Jun 26 2007

Keywords

  • Bronsted acids
  • Ion-pair catalysis
  • Piperidines
  • Reduction
  • Transfer hydrogenation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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