Optimization in Biology Parameter Estimation and the Associated Optimization Problem

Gunnar Cedersund, Oscar Samuelsson, Gordon Ball, Jesper Tegnér, David Gomez-Cabrero

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Parameter estimation—the assignment of values to the parameters in a model—is an important and time-consuming task in computational biology. Recent computational and algorithmic developments have provided novel tools to improve this estimation step. One of these improvements concerns the optimization step, where the parameter space is explored to find interesting regions. In this chapter we review the parameter estimation problem, with a special emphasis on the associated optimization methods. In relation to this, we also provide concepts and tools to help you select the appropriate methodology for a specific scenario.
Original languageEnglish (US)
Title of host publicationStudies in Mechanobiology, Tissue Engineering and Biomaterials
PublisherSpringer
Pages177-197
Number of pages21
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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