Optical and terahertz measurement techniques for flat-faced pharmaceutical tablets: A case study of gloss, surface roughness and bulk properties of starch acetate tablets

M. Juuti, H. Tuononen, T. Prykäri, V. Kontturi, M. Kuosmanen, E. Alarousu, J. Ketolainen, R. Myllylä, K. E. Peiponen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Surface and bulk properties of flat-faced starch acetate tablets were studied. For surface quality inspection optical coherence tomography and recently developed diffractive glossmeter were utilized. Both these optical devices together provide local information on surface roughness and gloss of a tablet over a measured area. The concepts of mean topography and mean gloss profile for surface quality of a tablet are introduced. It was observed that the surface quality of the tablet varies, and compression at high pressure may not guarantee a good surface quality of the tablet. Using novel statistical parameters for gloss and relevant surface roughness parameter, it is possible to get more comprehensive quantitative data on the surface condition of a tablet. THz spectrometer was utilized for detection of THz pulse delay in transmission measurement mode from the tablets. The delay time and thickness ratio of the tablet are consistent with the porosity of the tablet as a function of compression pressure. We suggest that the multimeasurement scheme using three different devices helps tablet makers to better assess bulk and surface quality of their products.

Original languageEnglish (US)
Article number015301
JournalMeasurement Science and Technology
Volume20
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Gloss measurement
  • Optical coherence tomography
  • Porosity
  • Roughness
  • Surface quality
  • Tablet
  • Terahertz spectroscopy

ASJC Scopus subject areas

  • Applied Mathematics
  • Instrumentation

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