Opening new operating windows for polymer and protein micronisation using the PCA process

Y. Pérez De Diego*, H. C. Pellikaan, F. E. Wubbolts, G. Borchard, G. J. Witkamp, P. J. Jansens

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

To avoid the existing limitations of the PCA process for the precipitation of proteins and polar polymers a new approach based on the use of water to modify the phase behaviour of the system DMSO-CO2 was developed. The addition of water to the DMSO displaces the mixture critical pressure of the solution-CO2 system to higher pressures and produces a new operating region in which the PCA process can be carried out. Following this approach, it was possible to develop a process to produce 1-10 μm particles of N-trimethylchitosan chloride (TMC) suitable for inhalation. Encapsulation of proteins in TMC using this technique could also be successfully achieved.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalJournal of Supercritical Fluids
Volume36
Issue number3
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Keywords

  • N-trimethylchitosan chloride
  • PCA
  • Polymer micronisation

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Science (miscellaneous)
  • Physics and Astronomy (miscellaneous)

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