One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere

Xinbo Wang, Yupeng Pan, Kuo-Wei Huang, Zhiping Lai

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.
Original languageEnglish (US)
Pages (from-to)5630-5633
Number of pages4
JournalOrganic Letters
Volume17
Issue number22
DOIs
StatePublished - Nov 6 2015

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