On the structure of PHB (=Poly[(R)-3-hydroxybutanoic acid]) in phospholipid bilayers: Preparation of trifluoromethyl-labeled oligo[(R)-3-hydroxybutanoic acid] derivatives

Magnus Rueping, Matthias Albert, Dieter Seebach*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Oligomers of (R)-3-hydroxybutanoate (OHB) have previously been shown to transport cations through lipid bilayers. The ion-transport activity has been attributed to the formation of hydrophobic aggregates or pores, which have been identified by fluorescence-microscopy measurements of membrane-incorporated fluorescence-labeled OHBs. To obtain more information about these aggregates, we describe here the synthesis of the specifically F-labeled HB oligomers II-IV for structural investigation by means of solid-state 19F-NMR spectroscopic techniques.

Original languageEnglish (US)
Pages (from-to)2473-2486
Number of pages14
JournalHelvetica Chimica Acta
Volume87
Issue number10
DOIs
StatePublished - Nov 26 2004

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'On the structure of PHB (=Poly[(R)-3-hydroxybutanoic acid]) in phospholipid bilayers: Preparation of trifluoromethyl-labeled oligo[(R)-3-hydroxybutanoic acid] derivatives'. Together they form a unique fingerprint.

Cite this