On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid

Ioanna Giouroudi, Sander van den Driesche, Jürgen Kosel, Roland Grössinger, Michael J. Vellekoop

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A biosensing principle utilizing the motion of suspended magnetic microparticles in a microfluidic system is presented. The system utilizes the innovative concept of the velocity dependence of magnetic microparticles (MPs) due to their volumetric change when analyte is attached to their surface via antibody–antigen binding. When the magnetic microparticles are attracted by a magnetic field within a microfluidic channel their velocity depends on the presence of analyte. Specifically, their velocity decreases drastically when the magnetic microparticles are covered by (nonmagnetic) analyte (LMPs) due to the increased drag force in the opposite direction to that of the magnetic force. Experiments were carried out as a proof of concept. A promising 52% decrease in the velocity of the LMPs in comparison to that of the MPs was measured when both of them were accelerated inside a microfluidic channel using an external permanent magnet. The presented biosensing methodology offers a compact and integrated solution for a new kind of on-chip analysis with potentially high sensitivity and shorter acquisition time than conventional laboratory based systems.
Original languageEnglish (US)
Pages (from-to)07B304
JournalJournal of Applied Physics
Volume109
Issue number7
DOIs
StatePublished - Mar 24 2011

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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