Numerical simulation of the stratum corneum's penetration property using finite element method

Yu Hong Liu*, Dirk Feuchter, Gabriel Wittum, En Ping Zhang, Yan Jun Zeng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

How could the outer substance penetrate through the skin lies on the stratum corneum, because it is the main barrier in the multi-layers of the skin. In this work, supposing the keratin cell with a special geometry as Tetrakaidecahedron, the discretization of the stratum corneum region was given at first in two steps: 1. The discretization of the keratin cell; 2. The discretization of fattiness that surrounds the keratin. Then numerical simulation was performed using finite element method and the multi-grid method. The former was to obtain the discretization of basic elements, the latter was to decrease the high frequency error. A visualization of the numerical simulation was shown in the paper.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalChinese Journal of Biomedical Engineering
Volume25
Issue number2
StatePublished - Apr 1 2006

Keywords

  • Discretization
  • Finite element method
  • Stratum corneum(SC)
  • Tetrakaidecahedron

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering

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