Nsite, NsiteH and NsiteM Computer Tools for Studying Tran-scription Regulatory Elements

Ilham Shahmuradov, Victor Solovyev

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Summary: Gene transcription is mostly conducted through interactions of various transcription factors and their binding sites on DNA (regulatory elements, REs). Today, we are still far from understanding the real regulatory content of promoter regions. Computer methods for identification of REs remain a widely used tool for studying and understanding transcriptional regulation mechanisms. The Nsite, NsiteH and NsiteM programs perform searches for statistically significant (non-random) motifs of known human, animal and plant one-box and composite REs in a single genomic sequence, in a pair of aligned homologous sequences and in a set of functionally related sequences, respectively.
Original languageEnglish (US)
Pages (from-to)3544-3545
Number of pages2
JournalBioinformatics
Volume31
Issue number21
DOIs
StatePublished - Jul 2 2015

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