Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements

Zhengzhong Zhou, Youchang Xiao, T. Alan Hatton, Tai-Shung Chung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Novel membrane processes for the effective enantioresolution of racemic mixtures have been evaluated. The incorporation of human serum albumin (HSA) in the strip solution of a permeation cell resulted in the partial optical resolution of a racemic tryptophan mixture, as the permeation of L-tryptophan, which binds to HSA more strongly, was enhanced selectively over that of D-tryptophan. A second approach in which a racemic mixture was introduced to the strip solution prior to the experiments showed better performance by selectively decreasing the flux of the more weakly bound D-tryptophan. The highest enantioselectivity of ~9.76 was achieved with a third, novel design consisting of two permeation cells in series, which can encompass the advantages of affinity dialysis. An industrial scale unit is proposed based on this concept and a suitably validated mathematical model.

Original languageEnglish (US)
Pages (from-to)1154-1162
Number of pages9
JournalAICHE Journal
Volume57
Issue number5
DOIs
StatePublished - May 1 2011

Keywords

  • Chiral separation
  • Enantiomers
  • Human serum albumin
  • Membrane separation
  • Selective permeation enhancement

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Biotechnology
  • Environmental Engineering

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