Noradrenergic System and Memory

Manuel Zenger, Sophie Burlet-Godinot, Jean-Marie Petit, Pierre J. Magistretti

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is ample evidence indicating that noradrenaline plays an important role in memory mechanisms. Noradrenaline is thought to modulate these procsses through activation of adrenergic receptors in neurons. Astrocytes that form essential partners for synaptic function, also express alpha- and beta-adrenergic receptors. In astrocytes, noradrenaline triggers metabolic actions such as the glycogenolysis leading to an increase in l-lactate formation and release. l-Lactate can be used by neurons as a sourc of energy during memory tasks and can also induc transcription of plasticity genes in neurons. Activation of β-adrenergic receptors can also trigger gliotransmitter release resulting of intracllular calcium waves. These gliotransmitters modulate the synaptic activity and thereby can modulate long-term potentiation mechanisms. In summary, recnt evidencs indicate that noradrenaline exerts its memory-promoting effects through different modes of action both on neurons and astrocytes.
Original languageEnglish (US)
Title of host publicationNoradrenergic Signaling and Astroglia
PublisherElsevier BV
Pages183-200
Number of pages18
ISBN (Print)9780128050880
DOIs
StatePublished - Jul 22 2017

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