Nonlinear neural network for hemodynamic model state and input estimation using fMRI data

Ayman M. Karam, Taous-Meriem Laleg-Kirati, Chadia Zayane, Nasser H. Kashou

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Originally inspired by biological neural networks, artificial neural networks (ANNs) are powerful mathematical tools that can solve complex nonlinear problems such as filtering, classification, prediction and more. This paper demonstrates the first successful implementation of ANN, specifically nonlinear autoregressive with exogenous input (NARX) networks, to estimate the hemodynamic states and neural activity from simulated and measured real blood oxygenation level dependent (BOLD) signals. Blocked and event-related BOLD data are used to test the algorithm on real experiments. The proposed method is accurate and robust even in the presence of signal noise and it does not depend on sampling interval. Moreover, the structure of the NARX networks is optimized to yield the best estimate with minimal network architecture. The results of the estimated neural activity are also discussed in terms of their potential use.
Original languageEnglish (US)
Pages (from-to)240-247
Number of pages8
JournalBiomedical Signal Processing and Control
Volume14
DOIs
StatePublished - Nov 2014

ASJC Scopus subject areas

  • Health Informatics
  • Signal Processing

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