We investigate the non-uniqueness of weak solutions of the Quantum-Hydrodynamic system. This form of ill-posedness is related to the change of the number of connected components of the support of the position density (called nodal domains) of the weak solution throughout its time evolution. We start by considering a scenario consisting of initial and final time, showing that if there is a decrease in the number of connected components, then we have non-uniqueness. This result relies on the Brouwer invariance of domain theorem. Then we consider the case in which the results involve a time interval and a full trajectory (position-current densities). We introduce the concept of trajectory-uniqueness and its characterization.