Non-invasive glucose sensing in scattering media using OCT, PAS and TOP techniques

Erkki Alarousu*, Jukka Hast, Matti Kinnunen, Mikhail Kirillin, Risto Myllylä, Jerzy Plucinski, Alexey Popov, Alexander Priezzhev, Tuukka Prykäri, Juha Saarela, Zhao Zuomin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid™ fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid™ was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

Original languageEnglish (US)
Article number5474-05
Pages (from-to)33-41
Number of pages9
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5
Issue number29
DOIs
StatePublished - 2004
Externally publishedYes

Keywords

  • Glucose sensing
  • OCT
  • PAS
  • Scattering media
  • TOF

ASJC Scopus subject areas

  • Engineering(all)

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