Non-classical therapeutic approach in the treatment of Alzheimer's disease: A mini review

V. Bajic, B. Spremo-Potparevic, L. Zivkovic, E. Sudar, S. Zafirovic, M. Obradovic, E.R. Isenovic

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics
Original languageEnglish (US)
JournalLetters in Drug Design and Discovery
Volume12
Issue number2
StatePublished - 2015

Keywords

  • [Amyloid aggregation inhibitors, Antioxidants, Bet

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