Niche-less maintenance of HSCs by 2i

Shigeo Masuda, Mo Li, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.

Original languageEnglish (US)
Pages (from-to)458-459
Number of pages2
JournalCell Research
Volume23
Issue number4
DOIs
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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