New encouraging developments in contact prediction: Assessment of the CASP11 results

Bohdan Monastyrskyy, Daniel D'Andrea, Krzysztof Fidelis, Anna Tramontano, Andriy Kryshtafovych

Research output: Contribution to journalArticlepeer-review

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Abstract

© 2015 Wiley Periodicals, Inc. This article provides a report on the state-of-the-art in the prediction of intra-molecular residue-residue contacts in proteins based on the assessment of the predictions submitted to the CASP11 experiment. The assessment emphasis is placed on the accuracy in predicting long-range contacts. Twenty-nine groups participated in contact prediction in CASP11. At least eight of them used the recently developed evolutionary coupling techniques, with the top group (CONSIP2) reaching precision of 27% on target proteins that could not be modeled by homology. This result indicates a breakthrough in the development of methods based on the correlated mutation approach. Successful prediction of contacts was shown to be practically helpful in modeling three-dimensional structures; in particular target T0806 was modeled exceedingly well with accuracy not yet seen for ab initio targets of this size (>250 residues).
Original languageEnglish (US)
Pages (from-to)131-144
Number of pages14
JournalProteins: Structure, Function, and Bioinformatics
Volume84
DOIs
StatePublished - Nov 17 2015
Externally publishedYes

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