Neuroenergetics: Calling upon Astrocytes to Satisfy Hungry Neurons

Luc Pellerin*, Pierre J. Magistretti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

211 Scopus citations

Abstract

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalNeuroscientist
Volume10
Issue number1
DOIs
StatePublished - Feb 2004
Externally publishedYes

Keywords

  • Aerobic glycolysis
  • Brain energy metabolism
  • Glucose
  • Lactate
  • Monocarboxylate transporters

ASJC Scopus subject areas

  • Neuroscience(all)

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