Networks of neuroblastoma cells on porous silicon substrates reveal a small world topology

Giovanni Marinaro, Rosanna La Rocca, Andrea Toma, Marianna Barberio, Laura Cancedda, Enzo M. Di Fabrizio, Paolo C W Decuzzi, Francesco T. Gentile

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The human brain is a tightly interweaving network of neural cells where the complexity of the network is given by the large number of its constituents and its architecture. The topological structure of neurons in the brain translates into its increased computational capabilities, low energy consumption, and nondeterministic functions, which differentiate human behavior from artificial computational schemes. In this manuscript, we fabricated porous silicon chips with a small pore size ranging from 8 to 75 nm and large fractal dimensions up to Df ∼ 2.8. In culturing neuroblastoma N2A cells on the described substrates, we found that those cells adhere more firmly to and proliferate on the porous surfaces compared to the conventional nominally flat silicon substrates, which were used as controls. More importantly, we observed that N2A cells on the porous substrates create highly clustered, small world topology patterns. We conjecture that neurons with a similar architecture may elaborate information more efficiently than in random or regular grids. Moreover, we hypothesize that systems of neurons on nano-scale geometry evolve in time to form networks in which the propagation of information is maximized. This journal is
Original languageEnglish (US)
Pages (from-to)184-197
Number of pages14
JournalIntegr. Biol.
Volume7
Issue number2
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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