Navigating the epigenetic landscape of pluripotent stem cells

Mo Li, Guang Hui Liu, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Pluripotent stem cells, which include embryonic stem cells and induced pluripotent stem cells, use a complex network of genetic and epigenetic pathways to maintain a delicate balance between self-renewal and multilineage differentiation. Recently developed high-throughput genomic tools greatly facilitate the study of epigenetic regulation in pluripotent stem cells. Increasing evidence suggests the existence of extensive crosstalk among epigenetic pathways that modify DNA, histones and nucleosomes. Novel methods of mapping higher-order chromatin structure and chromatin-nuclear matrix interactions also provide the first insight into the three-dimensional organization of the genome and a framework in which existing genomic data of epigenetic regulation can be integrated to discover new rules of gene regulation.

Original languageEnglish (US)
Pages (from-to)524-535
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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