Natural deep eutectic solvents as new potential media for green technology

Yuntao Dai, Jaap van Spronsen, Geert Jan Witkamp, Robert Verpoorte, Young Hae Choi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

940 Scopus citations

Abstract

Developing new green solvents is one of the key subjects in Green Chemistry. Ionic liquids (ILs) and deep eutectic solvents, thus, have been paid great attention to replace current harsh organic solvents and have been applied to many chemical processing such as extraction and synthesis. However, current ionic liquids and deep eutectic solvents have still limitations to be applied to a real chemical industry due to toxicity against human and environment and high cost of ILs and solid state of most deep eutectic solvents at room temperature. Recently we discovered that many plant abundant primary metabolites changed their state from solid to liquid when they were mixed in proper ratio. This finding made us hypothesize that natural deep eutectic solvents (NADES) play a role as alternative media to water in living organisms and tested a wide range of natural products, which resulted in discovery of over 100 NADES from nature. In order to prove deep eutectic feature the interaction between the molecules was investigated by nuclear magnetic resonance spectroscopy. All the tested NADES show clear hydrogen bonding between components. As next step physical properties of NADES such as water activity, density, viscosity, polarity and thermal properties were measured as well as the effect of water on the physical properties. In the last stage the novel NADES were applied to the solubilization of wide range of biomolecules such as non-water soluble bioactive natural products, gluten, starch, and DNA. In most cases the solubility of the biomolecules evaluated in this study was greatly higher than water. Based on the results the novel NADES may be expected as potential green solvents at room temperature in diverse fields of chemistry.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalAnalytica Chimica Acta
Volume766
DOIs
StatePublished - Mar 5 2013
Externally publishedYes

Keywords

  • Green technology
  • Ionic liquids
  • Natural deep eutectic solvents
  • Physicochemical properties
  • Solubility

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

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