Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles

Jing Zhang*, Dongliang Fu, Mary B. Chan-Park, Lain-Jong Li, Peng Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures.

Original languageEnglish (US)
Pages (from-to)790-793
Number of pages4
JournalAdvanced Materials
Volume21
Issue number7
DOIs
StatePublished - Feb 16 2009

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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