Nanoplasmonic and Microfluidic Devices for Biological Sensing

G. Perozziello, Andrea Giugni, Marco Allione, Bruno Torre, Gobind Das, M. L. Coluccio, Monica Marini, Luca Tirinato, Manola Moretti, Tania Limongi, P. Candeloro, Enzo M. Di Fabrizio

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

In this chapter we report about recent advances on the development and application of 2D and 3D plasmonic nanostructures used for sensing of biological samples by Raman spectroscopy at unprecedented resolution of analysis. Besides, we explain how the integration of these nanodevices in a microfluidic apparatus can simplify the analysis of biological samples. In the first part we introduce and motivate the convenience of using nanoplasmonic enhancers and Raman spectroscopy for biological sensing, describing the phenomena and the current approaches to fabricate nanoplasmonic structures. In the second part, we explain how specific multi-element devices produce the optimal enhancement of the Raman scattering. We report cases where biological sensing of DNA was performed at few molecules level with nanometer spatial resolutions. Finally, we show an example of microfluidic device integrating plasmonic nanodevices to sort and drive biological samples, like living cells, towards the optical probe in order to obtain optimal conditions of analysis.
Original languageEnglish (US)
Title of host publicationNATO Science for Peace and Security Series B: Physics and Biophysics
PublisherSpringer Nature
Pages247-274
Number of pages28
ISBN (Print)9789402408485
DOIs
StatePublished - Feb 17 2017

ASJC Scopus subject areas

  • Biophysics
  • Biotechnology
  • Electrical and Electronic Engineering
  • Physics and Astronomy(all)

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