"nanohybrids" based on pH-responsive hydrogels and inorganic nanoparticles for drug delivery and sensor applications

Andreas Riedinger, Manuel Pernia Leal, Smriti R. Deka, Chandramohan George, Isabella R. Franchini, Andrea Falqui, Roberto Cingolani, Teresa Pellegrino*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Allyl-PEG capped inorganic NPs, including magnetic iron oxide (IONPs), fluorescent CdSe/ZnS quantum dots (QDs), and metallic gold (AuNPs of 5 and 10 nm) both individually and in combination, were covalently attached to pH-responsive poly(2-vinylpyridine-co-divinylbenzene) nanogels via a facile and robust one-step surfactant-free emulsion polymerization procedure. Control of the NPs associated to the nanogels was achieved by the late injection of the NPs to the polymerization solution at a stage when just polymeric radicals were present. Remarkably, by varying the total amount of NPs injected, the swelling behavior could be affected. Furthermore, the magnetic response as well as the optical features of the nanogels containing either IONPs or QDs could be modified. In addition, a radical quenching in case of gold nanoparticles was observed, thus affecting the final nanogel geometry.

Original languageEnglish (US)
Pages (from-to)3136-3141
Number of pages6
JournalNano Letters
Volume11
Issue number8
DOIs
StatePublished - Aug 10 2011

Keywords

  • divinylbenzene
  • gold nanoparticles
  • pH responsive hydrogels
  • quantum dots
  • superparamagnetic nanoparticles
  • surfactant freeemulsion polymerization
  • vinylpyridine

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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