Hydrogen gas sensing were investigated using nano-bitter gourd like structured CuO material synthesized via a chemical route. Morphology of CuO was revealed using FE-SEM and TEM image analysis. CuO phase confirmation and molecular structural fingerprint were verified by XRD and Raman analysis respectively. Elemental composition and atomic states of elements were investigated by EDS and XPS techniques respectively. A remarkable high gas response of 175% was recorded by CuO sensor towards 100 ppm hydrogen (H) at the operating temperature 200 °C with response time 150 s. The lowest detection of H was observed at 2 ppm concentration with the gas response of 5%. The gas response was studied as functions of different operating temperatures and concentrations. Transient gas response and stability were also confirmed for CuO sensor. Hydrogen sensing mechanism of CuO sensor was elucidated.