"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

Wengang Li, Lin Deng, Basem Moosa, Guangchao Wang, Afnan Mashat, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.
Original languageEnglish (US)
Pages (from-to)476
JournalBiomaterials Science
Volume2
Issue number4
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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