N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates

Marc Magre, Marcin Szewczyk, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A new reduction of carbamates to N-methyl amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including N-Boc protected amines, into the corresponding N-methyl amines and amino alcohols which are of significant interest due to their presence in many biologically active molecules. Furthermore, the reduction can be extended to the formation of N-trideuteromethyl labeled amines.
Original languageEnglish (US)
JournalOrganic Letters
DOIs
StatePublished - Mar 27 2020

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