N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

Orlando Santoro, Faïma Lazreg, Yury Minenkov, Luigi Cavallo, Catherine S. J. Cazin

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.
Original languageEnglish (US)
Pages (from-to)18138-18144
Number of pages7
JournalDalton Trans.
Volume44
Issue number41
DOIs
StatePublished - 2015

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