N-Heterocyclic Carbene-Catalyzed Vinylogous Mukaiyama Aldol Reaction of α-Keto Esters and α-Trifluoromethyl Ketones

Guang-Fen Du, Ying Wang, Fen Xing, Mei Xue, Xu-Hong Guo, Kuo-Wei Huang, Bin Dai

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

© Georg Thieme Verlag Stuttgart · New York · Synthesis 2016. N-Heterocyclic carbene (NHC)-catalyzed vinylogous Mukaiyama aldol reaction of ketones was developed. Under the catalysis of 5 mol% NHC, α-keto esters and α-trifluoromethyl ketones reacted with 2-(trimethysilyloxy)furan efficiently to produce γ-substituted butenolides containing adjacent quaternary and tertiary carbon centers in high yields with good diastereoselectivities.
Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalSynthesis
Volume48
Issue number01
DOIs
StatePublished - Nov 4 2015

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