Multicomponent synthesis of unsymmetrical unsaturated N-heterocyclic carbene precursors and their related transition-metal complexes

Pierre Queval, Claire Jahier, Mathieu Rouen, Isabelle Artur, Jean Christophe Legeay, Laura Falivene, Loïc J. Toupet, Christophe Crévisy, Luigi Cavallo, Olivier Baslé, Marc Mauduit

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

A low-cost, modular, and easily scalable multicomponent procedure affording access in good yields and excellent selectivity (up to 93 %) to a wide range of (a)chiral unsymmetrical 1-aryl-3-cycloalkyl-imidazolium salts is disclosed. Electronic and steric properties of the corresponding unsymmetrical unsaturated N-heterocyclic carbene (U2-NHC) ligands were evaluated and evidenced strong electron donor ability, high steric discrimination, and modular steric demand. A low-cost, modular, and easily scalable multicomponent procedure, affording access to a wide range of (a)chiral unsymmetrical 1-aryl-3-cycloalkyl- imidazolium salts in good yields and excellent selectivities, is disclosed. Electronic and steric properties of the corresponding unsymmetrical unsaturated N-heterocyclic carbene (U2-NHC) ligands were evaluated and evidenced strong electron-donor ability, high steric discrimination, and modular steric demand. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish (US)
Pages (from-to)14103-14107
Number of pages5
JournalAngewandte Chemie International Edition
Volume52
Issue number52
DOIs
StatePublished - Dec 4 2013

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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