Modulation of burst frequency by calcium-dependent potassium channels in the lamprey locomotor system: Dependence of the activity level

Jesper Tegner*, Anders Lansner, Sten Grillner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

It is crucial to determine the effects on the network level of a modulation of intrinsic membrane properties. The role calcium-dependent potassium channels, K(Ca), in the lamprey locomotor system has been investigated extensively. Earlier experimental studies have shown that apamin, which affects one type of K(Ca), increases the cycle duration of the locomotor network, due to effects on the burst termination. The effects of apamin were here larger when the network had a low level of activity (burst frequency 0.5 to 1 Hz) as compared to a higher rate (> 2 Hz). By using a previously developed simulation model based on the lamprey locomotor network, we show that the model could account for the frequency dependence of the apamin modulation, if only the K(Ca) conductance activated by Ca2+ entering during the action potential was altered and not the K(Ca) conductance activated by Ca2+ entering through NMDA channels. The present simulation model of the spinal network in the lamprey can thus account for earlier experimental results with apamin on the network and cellular level that previously appeared enigmatic.

Original languageEnglish (US)
Pages (from-to)121-140
Number of pages20
JournalJournal of Computational Neuroscience
Volume5
Issue number2
DOIs
StatePublished - May 30 1998

Keywords

  • Computer simulation
  • K(Ca) channels
  • Modulation
  • Relaxation oscillator
  • Spinal circuits

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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