Modeling and simulation for three-dimensional signal propagation in passive dendrites

Christine Voßen, Jens P. Eberhard, Gabriel Wittum*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This paper presents a three-dimensional model for neuronal signal processing in passive dendritic branches. The approach is based on Maxwell's equations, in particular, on the equation of continuity for the electric flux. The quantities of interest are the electric potentials in the intra- and extracellular domain as well as the membrane voltage. The model is given by an integral Laplace equation with a source term that models the current through the membrane. We give results based on the numerical solution of the three-dimensional model, and we compare the model with the well known one-dimensional cable equation. One of the features of the new model is that it directly accounts for the possibility to include detailed measured geometry of dendritic branches into a three-dimensional numerical simulation. As a result, we are able to show for the first time that there is a significant impact of the extracellular domain into the solution of neuronal signal propagation in passive dendrites.

Original languageEnglish (US)
Pages (from-to)107-121
Number of pages15
JournalComputing and Visualization in Science
Volume10
Issue number2
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Software
  • Modeling and Simulation
  • Engineering(all)
  • Computer Vision and Pattern Recognition
  • Computational Theory and Mathematics

Fingerprint

Dive into the research topics of 'Modeling and simulation for three-dimensional signal propagation in passive dendrites'. Together they form a unique fingerprint.

Cite this