MINIMIZED SMALL PEPTIDES WITH HIGH AFFINITY FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS

Sebastian Knoer (Inventor), Horst Kessler (Inventor), Charlotte Hauser (Inventor), Evgueni Saenko (Inventor), Alexey Khrenov (Inventor)

Research output: Patent

Abstract

The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and peptide derivatives with affinity to coagulation Factor VIII and/or Factor VIII-like polypeptides and/or domains thereof. These compounds are useful for labeling, detecting, identifying, isolating and preferably for purifying, stabilizing and enhancing the activity of Factor VIII, Factor VIII-like polypeptides or domains thereof from physiological and non- physiological solutions comprising same. Further, these compounds may be used as ligands, which bind Factor VIII, Factor VIII-like polypeptides or domains thereof in methods of the present invention.

Original languageEnglish (US)
Patent numberWO2008003707
IPCG01N 33/ 68 A I
Priority date07/4/06
StatePublished - Jan 10 2008
Externally publishedYes

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