Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Zhiqiang Weng, Huaifeng Li, Weiming He, Liangfeng Yao, Jianwei Tan, Jinfa Chen, Yaofeng Yuan, Kuo-Wei Huang

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. © 2012 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)2527-2531
Number of pages5
JournalTetrahedron
Volume68
Issue number11
DOIs
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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