Mild and metal-free oxy- and amino-fluorination for the synthesis of fluorinated heterocycles

Dixit Parmar, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A mild intramolecular fluoro-cyclisation reaction of benzylic alcohols and amines has been developed. This strategy uses commercially available Selectfluor to trigger electrophilic cyclisations to afford fluorinated heterocycles containing 1,3-disubstitution. The dual role of the reagent as a fluorine source and a base is shown to be crucial for reactivity.

Original languageEnglish (US)
Pages (from-to)13928-13931
Number of pages4
JournalChemical Communications
Volume50
Issue number90
DOIs
StatePublished - Nov 21 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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