Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (α-aminoacyl)benzotriazoles

Alan R. Katritzky*, Nivine Khachab, Megumi Yoshioka, Danniebelle N. Haase, Krista R. Wilson, Jodie V. Johnson, Alfred Chung, Carrie Haskell-Luevano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(α-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.

Original languageEnglish (US)
Pages (from-to)465-468
Number of pages4
JournalChemical Biology and Drug Design
Volume70
Issue number5
DOIs
StatePublished - Nov 1 2007

Keywords

  • Microwave irradiation
  • N-Fmoc-protected(α-aminoacyl)benzotriazole
  • Peptides
  • Rink amide resin
  • Solid-phase peptide synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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