Microvilli Adhesion: An Alternative Route for Nanoparticle Cell Internalization

Patrizia Sommi, Agostina Vitali, Stefania Coniglio, Daniele Callegari, Sofia Barbieri, Alberto Casu, Andrea Falqui, Lorenzo Vigano’, Barbara Vigani, Franca Ferrari, Umberto Anselmi-Tamburini

Research output: Contribution to journalArticlepeer-review

Abstract

The cellular uptake of nanoparticles (NPs) represents a critical step in nanomedicine and a crucial point for understanding the interaction of nanomaterials with biological systems. No specific mechanism of uptake has been identified so far, as the NPs are generally incorporated by the cells through one of the few well-known endocytotic mechanisms. Here, an alternative internalization route mediated by microvilli adhesion is demonstrated. This microvillus-mediated adhesion (MMA) has been observed using ceria and magnetite NPs with a dimension of
Original languageEnglish (US)
Pages (from-to)15803-15814
Number of pages12
JournalACS Nano
Volume15
Issue number10
DOIs
StatePublished - Sep 29 2021

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Materials Science(all)
  • Engineering(all)

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