MicroRNAs contribute to induced pluripotent stem cell somatic donor memory

Marianna Vitaloni, Julian Pulecio, Josipa Bilic, Bernd Kuebler, Leopoldo Laricchia-Robbio, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: iPSCs retain marks of their donor population: "somatic donor memory," which facilitates iPSC differentiation back into their original tissue. Results: Specific microRNAs maintain their expression in HPC-derived iPSCs promoting their differentiation back to HPCs. Conclusion: miRNA contributes to iPSC somatic donor memory. Significance: miRNA donor memory may offer a tool to understand iPSC reprogramming and differentiation toward a particular somatic population.

Original languageEnglish (US)
Pages (from-to)2084-2098
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
StatePublished - Jan 24 2014

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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