MicroRNA Regulation of Stem Cell Fate and Reprogramming

Erika Lorenzo Vivas*, Gustavo Tiscornia, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Stem cells are seen as a new era in medicine due to their ability to differentiate and repopulate human tissues. Studies on their biology uncovered their incredible complexity and led to the creation of induced pluripotent stem cells (iPSc). MicroRNAs (miRNAs), in the beginning seen as an oddity, have been revealed as the cornerstone in the network regulating pluripotency and differentiation, becoming essential in understanding stem cell clockworks. In this chapter we try to clarify the role of miRNAs in the pluripotency-differentiation network, as well as their importance in regenerative medicine through reprogramming techniques.

Original languageEnglish (US)
Title of host publicationMicroRNAs in Medicine
PublisherWiley-Blackwell
Pages25-40
Number of pages16
ISBN (Electronic)9781118300312
ISBN (Print)9781118300398
DOIs
StatePublished - Nov 4 2013

Keywords

  • Pluripotency
  • Reprogramming
  • Stem cell
  • Transdifferentiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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