Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

Xiang Wang, Shunbo Li, Limu Wang, Xin Yi, Yu Sanna Hui, Jianhua Qin, Weijia Wen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.
Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Nanomaterials
Volume2013
DOIs
StatePublished - Sep 25 2013
Externally publishedYes

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