Microalbuminuria determination on a microchip with fluorescence detection based on thin-film organic light emitting diodes

O. Hofmann, X. Wang, J. C. DeMello, D. D.C. Bradley, A. J. DeMello

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

As a first step towards a disposable diagnostic microchip for determination of urinary human serum albumin (HSA), we report the use of a thin-film organic light emitting diode (OLED) as an excitation source for microscale fluorescence detection. The OLED has a peak emission at 540 nm, is simple to fabricate and operates at drive voltages below 10 V. In a PDMS microchip, HSA was reacted with Albumin Blue 580, generating a strong emission at 620 nm when excited with the OLED. HSA concentrations down to 10 mg/L could be detected, enabling the determination of microalbuminuria (MAU), an increased urinary albumin excretion indicative of renal disease. Copyright © 2005 by the Transducer Research Foundation, Inc.
Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundationinfo@transducer-research-foundation.org
ISBN (Print)0974361119
StatePublished - Jan 1 2005
Externally publishedYes

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