Michael-Michael ring closure reaction of benzyl cyanides and chalcones

M. M. Al-Arab*, B. S. Ghanem, M. M. Olmstead

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The synthesis of a number of highly substituted cyclohexane derivatives has been accomplished in a single step reaction of benzyl cyanides and chalcones (1:2) using sodium ethoxide in anhydrous diethyl ether at room temperature to give 3-aroyl-1,2,4,6-tetraaryl-4-hydroxycyclohexanecarbonitriles. An unambiguous structural assignment was achieved from the analytical and infrared, 1H NMR and 13C NMR spectroscopic data as well as X-ray crystallography.

Original languageEnglish (US)
Pages (from-to)1003-1006
Number of pages4
JournalSynthesis
Issue number10
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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