Micelles and polymersomes obtained by self-assembly of dextran and polystyrene based block copolymers

Clément Houga, Joanna Giermanska, Sélbastien Lecommandoux, Redouane Borsali, Daniel Taton, Yves Gnanou*, Jean François Le Meins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

The self-assembly of dextran-block-polystyrene (dex-b-PS) block copolymers was investigated in solution. The hydrophobic PS weight fraction in these block copolymers ranges from 7 to 92% w/w, whereas the average number molar mass of dextran was kept constant at 6600 gmol-1. Self-assembly by direct dissolution in water could be performed only for block copolymers with a low hydrophobic content (7% w/w), whereas mixtures of tetrahydrofuran and dimethylsulfoxide were required for higher PS content, before transferring the structures into water. Coreshell micelles, ovoïlds, and vesicles could be identified upon characterization by light and neutrons scattering, atomic force microscopy, and transmission electron microscopy. Most of the morphologies observed were not expected considering the chemical composition of the block copolymers. Finally, the size and shape of these nanoparticles were fixed upon cross-linking the dextran block through reaction of the hydroxyl groups with divinylsulfone. The role of the dextran conformation on the self-assembly process is discussed.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalBiomacromolecules
Volume10
Issue number1
DOIs
StatePublished - Jan 12 2009

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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