Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

Marta Cal, Aleksandra Kotynia, Lukasz Jaremko, Mariusz Jaremko, Marek Lisowski, Małgorzata Cebo, Justyna Brasuń, Piotr Stefanowicz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu2+ ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu2+ ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L4Cu5 complexes exist at physiological pH in the presence of Cu2+ ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.

Original languageEnglish (US)
Pages (from-to)11172-11181
Number of pages10
JournalDalton Transactions
Volume44
Issue number24
DOIs
StatePublished - Jun 28 2015

ASJC Scopus subject areas

  • Inorganic Chemistry

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