Metal-free Brønsted acid catalyzed transfer hydrogenation - New organocatalytic reduction of quinolines

Magnus Rueping*, Thomas Theissmann, Andrey P. Antonchick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

The first metal-free Brønsted acid catalyzed hydrogenation of quinolines using Hantzsch dihydropyridine as the hydrogen source has been developed. This, so far unprecedented organocatalytic reduction of heteroaromatic compounds provides a variety of differently substituted 1,2,3,4-tetrahydroquinolines in excellent yields under mild reaction conditions using a remarkably low amount of Brønsted acid catalyst.

Original languageEnglish (US)
Pages (from-to)1071-1074
Number of pages4
JournalSynlett
Issue number7
DOIs
StatePublished - May 3 2006

Keywords

  • 1,2,3,4-tetrahydroquinoline
  • Brønsted acid
  • Hantzsch dihydropyridine
  • Organocatalysis
  • Reduction
  • Transfer hydrogenation

ASJC Scopus subject areas

  • Organic Chemistry

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