Metal-conjugated affinity labels: A new concept to create enantioselective artificial metalloenzymes

Thomas Reiner, Dominik Jantke, Alexander N. Marziale, Andreas Raba, Jörg Eppinger

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

How to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82% e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions. 2013 The Authors.
Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalChemistryOpen
Volume2
Issue number2
DOIs
StatePublished - Feb 20 2013

ASJC Scopus subject areas

  • Chemistry(all)

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